Fastonib-5

Indications

Tofacitinib is commonly prescribed for the following conditions:

• Rheumatoid Arthritis (RA): For moderate to severe active rheumatoid arthritis in adults who have not responded adequately to methotrexate or other disease-modifying antirheumatic drugs (DMARDs).
• Psoriatic Arthritis (PsA): For active psoriatic arthritis in adults.
• Ulcerative Colitis (UC): For moderate to severe active ulcerative colitis in adults who have not responded to conventional therapy.
• Other conditions: May be used for other inflammatory conditions as determined by a healthcare provider.

Dosage and Administration

Rheumatoid Arthritis:

- Initial dose: 5 mg twice daily.

- Maintenance: 5 mg twice daily.

Psoriatic Arthritis:

- 5 mg twice daily.

Ulcerative Colitis:

- Initial dose: 10 mg twice daily for 8 weeks, then reduced to 5 mg twice daily or 10 mg once daily depending on response.

Tofacitinib is taken orally, with or without food.

Precautions

Infection Risk: Tofacitinib can increase the risk of serious infections such as tuberculosis, bacterial, fungal, or viral infections. Patients should be screened for infections before starting treatment.

Liver Function: Monitor liver enzymes, as tofacitinib may affect liver function.

Blood Counts: Monitor blood cell counts (white blood cells, red blood cells, and platelets), as tofacitinib can cause blood disorders.

Vaccination: Patients should be up to date on vaccinations before starting treatment, as live vaccines should be avoided during therapy.

Pregnancy and Breastfeeding: Not recommended during pregnancy and breastfeeding unless clearly necessary. Consult a doctor for risk assessment.

Kidney and Heart Conditions: Patients with kidney or heart issues should be closely monitored.