Nvrest inj.
NVREST Inj. is an intravenous or intramuscular injection containing Ondansetron, a selective serotonin 5-HT3 receptor antagonist. It is primarily used to prevent and treat nausea and vomiting associated with chemotherapy, radiation therapy, surgery, or other medical treatments.
- Recommended Usage
Indications
- Chemotherapy-induced nausea and vomiting (CINV) – for preventing nausea and vomiting caused by chemotherapy.
- Radiotherapy-induced nausea and vomiting (RINV) – to prevent and treat nausea and vomiting associated with radiation therapy.
- Postoperative nausea and vomiting (PONV) – to prevent and treat nausea and vomiting following surgery.
- Other causes of nausea and vomiting as prescribed by a healthcare provider.
Dosage and Administration
Typical Dose for Adults:
- Chemotherapy and Radiation:
-- IV/IM injection: A typical dose is 8 mg of Ondansetron administered 30 minutes before chemotherapy or radiation treatment, followed by additional doses as needed.
- Postoperative Nausea and Vomiting (PONV):
-- IV/IM injection: 4 mg administered before or immediately after surgery, with additional doses as required.
- o Maximum Daily Dose: For most indications, the typical daily dose should not exceed 32 mg.
Administration:
- IV administration: Inject slowly over 2 minutes.
- IM administration: Direct injection into a muscle.
- Note: Dose adjustments may be needed for elderly patients or those with hepatic impairment.
Precautions
Hypersensitivity: Avoid in patients with known hypersensitivity to Ondansetron or any of its components.
Cardiac Issues: Caution is advised in patients with electrolyte imbalances, congenital long QT syndrome, or those receiving medications that affect the heart’s rhythm, as Ondansetron can prolong the QT interval.
Serotonin Syndrome: Rare, but possible when combined with other serotoninergic medications (e.g., SSRIs, SNRIs). Symptoms include agitation, confusion, fever, shivering, and muscle twitching. Immediate medical attention is needed if these symptoms occur.
Pregnancy and Breastfeeding: Ondansetron is classified as a Category B drug during pregnancy, meaning it should be used during pregnancy only if clearly needed. It is excreted in breast milk, so it should be used with caution in breastfeeding mothers.
Hepatic Impairment: The dose should be reduced in patients with severe liver impairment (Child-Pugh Class C).
Benefits
Effective Anti-Nausea: Highly effective for preventing and treating nausea and vomiting caused by chemotherapy, radiation, and surgery.
Rapid Onset: Works quickly to alleviate nausea and vomiting, providing relief shortly after administration.
Versatile: Suitable for use in various settings, including chemotherapy centers, surgical recovery rooms, and hospital wards.
Convenient Dosing: Available as an injectable form for those who cannot take oral medications or need rapid relief.
Minimal Sedation: Unlike some other anti-nausea medications, Ondansetron does not cause significant sedation or drowsiness.
